Assessing Complex Left Ventricular Adaptations in Aortic Stenosis Using Personalized 3D  + time Cardiac MRI Modeling

This study proposed and assessed the feasibility of using a motion-corrected personalized 3D  + time LV modeling technique to evaluate the adaptive and maladaptive LV response to aid treatment decision-making. A total of 22 AS patients were analyzed and compared against 10 healthy subjects. The 3D + time analysis showed a highly distinct and personalized pattern of remodeling in ind ividual AS patients which is associated with comorbidities and fibrosis. Patients with AS alone showed better wall thickening and synchrony than those comorbid with hypertension. Ischemic heart disease in AS caused impaired wall thickening and synchrony and systolic function. Apart from showing sign ificant correlations to echocardiography and clinical MRI measurements (r: 0.70 –0.95;p <  0.01), the proposed technique helped in detecting subclinical and subtle LV dysfunction, providing a better approach to evaluate AS patients for specific treatment, surgical planning, and follow-up recovery.
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research