Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito ‐borne viruses

Mosquito salivary proteins (MSPs) bear multitudinous functions, embracing facilitating blood feeding and affecting the infection of mosquito-borne viruses (MBVs)via directly interplaying with MBVs or tuning the homeostasis of host cells.In vivo, MSPs can modulate host's innate and adaptive immunity, which in turn impacts the native infection at the bite site and the remote dissemination of MBVs. MSP-based MBV transmission-blocking vaccines are neoteric and effective tactics to stifle the MBV transmission. AbstractMosquito-borne viruses (MBVs) are a large class of viruses transmitted mainly through mosquito bites, including dengue virus, Zika virus, Japanese encephalitis virus, West Nile virus, and chikungunya virus, which pose a major threat to the health of people around the world. With global warming and extended human activities, the incidence of many MBVs has increased significantly. Mosquito saliva contains a variety of bioactive protein components. These not only enable blood feeding but also play a crucial role in regulating local infection at the bite site and the remote dissemination of MBVs as well as in remodeling the innate and adaptive immune responses of host vertebrates. Here, we review the physiological functions of mosquito salivary proteins (MSPs) in detail, the influence and the underlying mechanism of MSPs on the transmission of MBVs, and the current progress and issues that urgently need to be addressed in the research and development of MSP-based MBV tra...
Source: Insect Science - Category: Biology Authors: Tags: REVIEW Source Type: research