Lesional Antibody Synthesis and Complement Deposition Associate With De Novo Antineuronal Antibody Synthesis After Spinal Cord Injury

This study provides immunologic, neurobiological, and neuropathologic proof-of-principle for an antibody-mediated autoimmunity response emerging approximately 3 weeks after SCI in a patient subpopulation with a high demand of neuropathic pain medication. Emerging autoimmunity directed against specific spinal cord and neuronal epitopes suggests the existence of paratraumatic CNS autoimmune syndromes.

Source: Neurology Neuroimmunology and Neuroinflammation - April 5, 2023 Category: Neurology Authors: Schwab, J. M., Haider, C., Kopp, M. A., Zrzavy, T., Endmayr, V., Ricken, G., Kubista, H., Haider, T., Liebscher, T., Lübstorf, T., Blex, C., Serdani-Neuhaus, L., Curt, A., Cinelli, P., Scivoletto, G., Fehlings, M. G., May, C., Guntermann, A., Marc Tags: Autoimmune diseases, Spinal cord trauma, Cerebrospinal Fluid Research Article Source Type: research