Effects on survival of the adverse event of atezolizumab plus bevacizumab for hepatocellular carcinoma: a multicenter study by the Japan Red Cross Liver Study Group

This study aimed to describe the real-world efficacy and safety of the combination therapy of atezolizumab and bevacizumab (Atezo/Bev) for unresectable hepatocellular carcinoma (HCC). This retrospective analysis of a multicenter registry cohort included 268 patients treated with Atezo/Bev. The incidence of adverse events (AE) and its impact on overall survival (OS) and progression-free survival (PFS) were analyzed. Of the 268 patients, 230 (85.8%) experienced AE. The median OS and PFS in the whole cohort were 462 and 239 days, respectively. The OS and PFS were not different in terms of AE, but they were significantly shorter in patients with increased bilirubin level and those with increased aspartate aminotransferase (AST) or alanine aminotransferase (ALT). Regarding increased bilirubin level, the hazard ratios (HRs) were 2.61 (95% confidence interval [CI]: 1.04 –6.58,P = 0.042) and 2.85 (95% CI: 1.37 –5.93,P = 0.005) for OS and PFS, respectively. Regarding increased AST or ALT, the HRs were 6.68 (95% CI: 3.22 –13.84,P< 0.001) and 3.54 (95% CI: 1.83 –6.86,P< 0.001) for OS and PFS, respectively. Contrarily, the OS was significantly longer in patients with proteinuria (HR: 0.46 [95% CI: 0.23 –0.92],P = 0.027). Multivariate analysis confirmed that proteinuria (HR: 0.53 [95% CI: 0.25 –0.98],P = 0.044) and increased AST or ALT (HR: 6.679 [95% CI: 3.223 –13.84],P = 0.003) were independent risk factors for a shorter OS. Furthermore, analysis limited to cases who...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research