A double-blinded, placebo-controlled, randomized study to evaluate the efficacy of perioperative dextromethorphan compared to placebo for the treatment of postoperative pain: a study protocol

This study has a number of strengths including adequate power, a randomized controlled design, and an evidence-based dosing schedule. As such, it will provide the most robust evidence to date on dextromethorphan utilization for postoperative pain control following TKA. Limitations include not obtaining serum samples for pharmacokinetic analysis and the single-center study design.Trial registrationThis trial has been registered on the National Institute of Health ’sClinicalTrials.gov (NCT number: NCT05278494). Registered on March 14, 2022.
Source: Trials - Category: Research Source Type: clinical trials