Clinical outcome of ulcerative colitis with severe onset in children: a multicenter prospective cohort study

ConclusionsChildren with severe ulcerative colitis are likely to require powerful agents such as calcineurin inhibitors and biologic agents; sometimes colectomy ultimately proves necessary. Need for biologic agents in steroid-resistant patients might be reduced to an extent by interposing a therapeutic trial of CI rather than turning to biologic agents or colectomy immediately.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research