Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis

ConclusionOur findings demonstrated for the first time that P-Rex1 was an essential signaling mediator in CFs activation and subsequent cardiac fibrosis, and 1A-116 could be a potential pharmacological development drug.

http://link.springer.com/10.1007/s10557-023-07442-3

Source: Cardiovascular Drugs and Therapy - March 9, 2023 Category: Cardiology Source Type: research