FEMA GRAS assessment of natural flavor complexes: Lemongrass oil, chamomile oils, citronella oil and related flavoring ingredients

Food Chem Toxicol. 2023 Mar 2:113697. doi: 10.1016/j.fct.2023.113697. Online ahead of print.ABSTRACTIn 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, eleventh in the series, evaluates the safety of NFCs characterized by primary alcohol, aldehyde, carboxylic acid, ester and lactone constituents derived from terpenoid biosynthetic pathways and/or lipid metabolism. The Expert Panel uses the scientific-based evaluation procedure published in 2005 and updated in 2018 that relies on a complete constituent characterization of the NFC intended for commerce and organization of the constituents of each NFC into well-defined congeneric groups. The safety of the NFCs is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on estimated intake, metabolism and toxicology of members of the congeneric groups and for the NFC under evaluation. The scope of the safety evaluation contained herein does not include added use in dietary supplements or any products other than food. Twenty-three NFCs, derived from the Hibiscus, Melissa, Ricinus, Anthemis, Matricaria, Cymbopogon, Saussurea, Spartium, Pelargonium, Levisticum, Rosa, Santalum, Viola, Cryptocarya and Litsea genera were affirmed as generally recognized as safe (GRAS) under their conditions of i...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Source Type: research