Integrated Genetic Profiling of Archival Pediatric High-Grade Glial Tumors and Reassessment with 2021 WHO Classification of Paediatric CNS Tumours

Central nervous system (CNS) tumors are the most common type of pediatric solid tumors and the leading cause of cancer-related deaths in childhood [24,31,32]. Of all childhood CNS tumors, high-grade gliomas account for most of the tumor-related deaths. Pediatric high-grade gliomas (pHGG) are rare, with only two to three cases per 100,000 in the United States annually, and the overall survival rate for children under the age of 19 years who have pHGG remains dismal even with newer diagnostics and therapeutics [24].

Source: Cancer Genetics and Cytogenetics - March 3, 2023 Category: Genetics & Stem Cells Authors: Linda D Cooley, Lisa A Lansdon, Kris Laurence, John C Herriges, Lei Zhang, Elena A Repnikova, Julie Joyce, Preeti Thakor, Lisa Warren, Scott C Smith, Byunggil Yoo, Melissa Gener, Kevin F Ginn, Midhat S Farooqi Tags: Original Article Source Type: research