Drp1/p53 interaction mediates p53 mitochondrial localization and dysfunction in septic cardiomyopathy
Previous studies have implicated p53-dependent mitochondrial dysfunction in sepsis induced end organ injury, including sepsis-induced myocardial dysfunction (SIMD). However, the mechanisms behind p53 localization to the mitochondria have not been well established. Dynamin-related protein 1 (Drp1), a mediator of mitochondrial fission, may play a role in p53 mitochondrial localization. Here we examined the role of Drp1/p53 interaction in SIMD using in vitro and murine models of sepsis.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Riddhita Mukherjee, Laura H. Tetri, Sin-Jin Li, Giovanni Fajardo, Nicolai P. Ostberg, Kaleb B. Tsegay, Kanika Gera, Timothy T. Cornell, Daniel Bernstein, Daria Mochly-Rosen, Bereketeab Haileselassie Source Type: research