Indomethacin restores loss of hippocampal neurogenesis and cholinergic innervation and reduces innate immune expression and reversal learning deficits in adult male and female rats following adolescent ethanol exposure

CONCLUSIONS: These data suggest that in males and females, (1) AIE persistent neuroimmune induction mediates both the loss of adult hippocampal DCX and loss of basal forebrain cholinergic neurons and their innervation to hippocampal targets, and (2) anti-inflammatory indomethacin treatment following AIE that restores these persistent molecular pathologies also restores spatial reversal learning deficits.PMID:36799290 | DOI:10.1111/acer.15019

Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Victoria Macht Ryan Vetreno Natalie Elchert Rachael Fisher Fulton Crews Source Type: research