Correspondence on 'Lymphogranuloma venereum mimicking squamous cell carcinoma by Sara Tormo-Mainar et al

A man living with HIV receiving virologically suppressive antiretroviral therapy with preserved CD4 cell count presented with a 1-month history of a painful, large verrucous lesion on the left buttock (figure 1A). The differential diagnosis included mainly verrucous squamous cell carcinoma and lymphogranuloma venereum (LGV). Chronic herpes simplex virus infection or Buschke-Löwenstein tumour was considered less likely. A biopsy demonstrated pseudoepitheliomatous hyperplasia and dermal inflammatory infiltrates (figure 1B). Molecular testing detected Chlamydia trachomatis serovar L2. Twenty-one days of doxycycline (100 mg two times per day) induced a partial clinical response; treatment for further 21 days was followed by an atrophic scar and chronic lymphoedema. A test of cure was negative 3 months later. LGV can present as fluctuant lymph nodes, proctocolitis or, more rarely, an oropharyngeal syndrome or a local inflammatory mass.1 First-line treatment is doxycycline for 21 days, but prolonged therapy might be required...

Source: Sexually Transmitted Infections - February 17, 2023 Category: Sexual Medicine Authors: Tormo-Mainar, S., Marcantonio, O. Y., Deza, G., Martin-Ezquerra, G. Tags: PostScript Source Type: research