Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region

ConclusionsHaplotypes in theIFNG andIL6 genes have been correlated to serum levels of IFN- γ, IL-2 and IL-18, and a moderate effect has been found onIL8 haplotype correlated to IL-8 and IL-18 serum levels. The results indicate that the resistance toL. infantum infection could be a consequence of certain haplotypes with a high frequency in the Ibizan Hound dog breed, while susceptibility to the disease would be related to other specific haplotypes, with high frequency in Boxer. Future studies are needed to elucidate whether these differences and haplotypes are related to different phenotypes in immune response and expression gene regulation toL. infantum infections in dogs and their possible application in new treatments and vaccines.Graphical Abstract
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research