Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory –entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases

ConclusionsAlteration in the OT proteostasis was more severe in AD than in PD. Moreover, protein expression changes were more abundant in women than men independent of the neurological syndrome. Mechanistically, the tangled SIRT profile observed across the olfactory pathway-associated brain regions in AD and PD indicates differential NAD (+)-dependent deacetylase mechanisms between women and men. All these data shed new light on differential olfactory mechanisms across AD and PD, pointing out that the evaluation of the feasibility of emerging sirtuin-based therapies against neurodegenerative diseases should be considered with caution, including further sex dimension analyses in vivo and in clinical studies.
Source: Biology of Sex Differences - Category: Biology Source Type: research