No good deed: Acidosis in chronic kidney and liver disease.

Studies have shown that low or high serum bicarbonate levels (reflecting metabolic acidosis or alkalosis)are associated with increased all-cause mortality rates in moderate and advanced chronic kidney disease (CKD) cases. Correction of presumed acidosis using sodium bicarbonate, targeting serum levels around 22 mmol/l, has proven beneficial in delaying the progression of the disease and provided mortality benefit. A similar prognostic association may exist between uncorrected metabolic acidosis in chronic liver disease.

Source: Journal of Renal Nutrition - January 31, 2023 Category: Urology & Nephrology Authors: Samira Chandra, Sreelakshmi Ravula, Praveen Errabelli, Horace Spencer, Manisha Singh Tags: Clinical Brief Source Type: research