Reversine Increases Cell Plasticity, and Appears to Allow Some Cell Types to Escape Senescence

If I'm understanding the results presented here correctly, the reversine small molecule enables senescent cells to return to a more normal state of function, including replication, at least in muscle cells examined in cell culture. The researchers believe it is triggering some of the same reprogramming pathways as the Yamanaka factors, perhaps by inducing expression of Oct4, but are not yet certain as to what is going on under the hood. Is it a good idea to take senescent cells in the body and return them to normal function? That is a good question, and has been raised for other approaches to senescence reversal. At least some senescent cells are senescent for a good reason, being damaged in ways that may lead to cancer, and all senescent cells undergo significant DNA damage in the process of becoming senescent. Reversal of senescence, versus just destroying senescent cells, sounds a lot like a cancer waiting to happen. Skeletal muscle has a remarkable capacity to regenerate by activation of myogenic progenitor cells; however, both the number of these progenitors and their regenerative capacity decline with aging and cellular senescence. Metabolic changes such as impaired glycolysis, insulin sensitivity, and mitochondrial respiration are affected by senescence contributing to loss of the myoblast capacity to differentiate. Aging is also associated with impaired autophagy, which is essential to maintain satellite cell stemness and mitochondrial turn over. Seve...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs