The effect of adjusting LDL-cholesterol for Lp(a)-cholesterol on the diagnosis of Familial Hypercholesterolaemia

Familial Hypercholesterolaemia (FH) is a common monogenic disorder of low-density-lipoprotein cholesterol (LDL-C) associated with premature cardiovascular disease (CVD).1 Untreated, the cumulative incidence of ischaemic heart disease in men and women is 50% by age 50, and 60% by age 60, respectively.2 The 2013 consensus panel statement from the European Atherosclerosis Society highlights that FH is underdiagnosed and undertreated, and a ‘call to arms’ was recently issued to address screening, diagnosis, and treatment, supported by development of a global FH registry: the European Atherosclerosis Society FH Studies Collaboration.

Source: Journal of Clinical Lipidology - January 25, 2023 Category: Lipidology Authors: Darmiga Thayabaran, Anson .P.T. Tsui, Stefan Ebmeier, Jaimini Cegla, Alessia David, Ben Jones Source Type: research