Familial risk of epithelial ovarian cancer after accounting for gynaecological surgery: a population-based study

Conclusion Familial risk of epithelial ovarian cancer extends to TDRs, especially for high-grade serous and mucinous histotypes. Distant relatives share genes but minimal environment, highlighting the importance of germline inherited genetics in ovarian cancer aetiology. Increased ovarian cancer risk in distant relatives has implications for counselling and recommendations for prophylactic surgeries that, from our data, appear only to reach FDRs.
Source: Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Open access Cancer genetics Source Type: research