Stomach and duodenum dose –volume constraints for locally advanced pancreatic cancer patients treated in 15 fractions in combination with chemotherapy

ConclusionIn a large cohort treated with hypofractionated radiotherapy for LAPC, the risk of duodenal/gastric toxicities was associated with duodenum/stomach DVH. Constraining duodenum V44Gy < 9.1 cc, stomach V44Gy < 2 cc, and stomach D0.03 < 45 Gy should keep the toxicity rate at approximately or below 5%. The association with duodenum D0.03 was not sufficiently robust due to the limited number of events, although results suggest that a limit of 45–46 Gy should be safe.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research