Role of Tumor Necrosis Factor Receptor 1-Reactive Oxygen Species-Caspase 11 Pathway in Neuropathic Pain Mediated by HIV gp120 With Morphine in Rats

CONCLUSIONS: These results suggest that spinal TNFRI-mtROS-caspase 11 signal pathway plays a critical role in the HIV-associated neuropathic pain state, providing a novel approach to treating chronic pain in PLWH with opioids.PMID:36662639 | DOI:10.1213/ANE.0000000000006335

Source: Anesthesia and Analgesia - January 20, 2023 Category: Anesthesiology Authors: Kentaro Hayashi Hyun Yi Xun Zhu Shue Liu Jun Gu Keiya Takahashi Yuta Kashiwagi Marta Pardo Hirotsugu Kanda Heng Li Roy C Levitt Shuanglin Hao Source Type: research