LH increases the response to FSH in granulosa-lutein cells from sub/poor-responder patients in vitro

In conclusion, FSH elicits phenotype-specific ovarian lutein cell response. Most importantly, LH addition may fill the gap between cAMP and steroid production patterns between normo- and sub/poor-responders.LIMITATIONS, REASONS FOR CAUTIONAlthough the number of experimental replicates is overall high for anin vitro study, clinical trials are required to demonstrate if the endpoints evaluated herein reflect parameters of successful ART. hGLC retrieved after ovarian stimulation may not fully reproduce the response to hormones of granulosa cells from the antral follicular stage.WIDER IMPLICATIONS of THE FINDINGSThisin vitro assay may describe the individual response to personalize ART stimulation protocol, according to the normo-, sub- and poor-responderstatus. Moreover, thisin vitro study supports the need to conduct optimally designed, randomized clinical trials exploring the personalized use of LH in assisted reproduction.STUDY FUNDING/COMPETING INTEREST(S)This study was supported by Merck KGaA. M.L. and C.C. are employees of Merck KGaA or of the affiliate Merck Serono SpA. Other authors have no competing interests to declare.TRIAL REGISTRATION NUMBERN/A.
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research