Neuroinflammation Is a Prominent Feature of Alzheimer ' s Disease

Researchers are increasingly considering chronic, unresolved inflammation in brain tissue to be an important pathological mechanism in Alzheimer's disease. Removing senescent cells from the brain has reduced pathology in mouse models of Alzheimer's disease. While, as ever, the issue with all such models is their artificiality, as mice do not naturally suffer anything resembling Alzheimer's disease, it is well established that inflammation is a feature of Alzheimer's disease in humans. We have a good idea as to the major causes of this inflammation: senescent cells, an altered gut microbiome, debris from stressed cells that provokes an innate immune reaction, and so forth. Targeting the causes of excessive inflammation without suppressing the whole immune response may well prove to be a useful preventative treatment for many age-related conditions. Alzheimer's disease (AD) should be viewed as a systemic disease that involves dynamic processes in the peripheral and central immune compartments. The conceptualization of the pathogenesis of AD remains elusive, with many competing hypotheses, particularly those based on proteopathic and immunopathic mechanisms. The peripheral and central immune systems are dysregulated in AD and are related to the cognitive function and clinical status. They may change in a non-linear manner over time, and burgeoning evidence also suggests that the roles of the innate and adaptive immune processes differ depending on the pathological stage...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs