Globular adiponectin-mediated vascular remodeling by affecting the secretion of adventitial-derived tumor necrosis factor- α induced by urotensin II

ConclusionsFrom the results of our study, we can speculate that UII induces TNF- α protein and TNF-α-R secretion in AFs and rat tunica adventitia of vessels via the Rho and PKC signal transduction pathways. Thus, it is plausible that adiponectin is a major player in adventitial progression and could serve as a novel therapeutic target for cardiovascular disease administration.
Source: Journal of Zhejiang University. Science. B. - Category: Universities & Medical Training Source Type: research