Prevention of Radiation-Induced Bladder Injury: A Murine Study Using Captopril
Pelvic radiation therapy (RT) can cause debilitating bladder toxicities but few clinical interventions exist to prevent injury or alleviate symptoms. From a large genome-wide association study in patients with prostate cancer it was previously reported that SNPs tagging AGT, part of the renin-angiotensin system (RAS), correlated with patient-reported late hematuria, identifying a potential targetable pathway to prevent RT-induced bladder injury. To investigate this association, we performed a preclinical study to determine whether RAS modulation protected the bladder against RT injury.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Angela M. Groves, Nicole Paris, Eric Hernady, Carl J. Johnston, Omar Aljitawi, Yi-Fen Lee, Sarah L. Kerns, Brian Marples Tags: BIOLOGY CONTRIBUTION Source Type: research
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