Mild traumatic brain injury attenuates pneumonia-induced lung injury by modulations of alveolar macrophage bactericidal activity and m1 polarization

In this study, we used a murine model of MTBI and pneumonia (Pseudomonas aeruginosa;) to explore the relationship between these conditions and the underlying mechanism. Methods: Mice (n = 104) were divided into control, MTBI, pneumonia, and MTBI + pneumonia groups. MTBI was induced by the weight-drop method. Pneumonia was induced by intratracheal injection with P. aeruginosa Xen5 strain. Animals were killed 24 h after bacterial challenging. Histological, cellular, and molecular indices of brain and lung injury were assessed using various methods. Results: Mice in both the MTBI and pneumonia groups had more Fluoro-Jade C–positive neurons than did the controls (P
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research