Impact of the eicosapentaenoic acid to arachidonic acid ratio on plaque characteristics in statin-treated patients with coronary artery disease

A low eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is an indicator of increased risk for cardiovascular events 1,2. Preclinical and clinical studies have demonstrated that EPA stabilizes plaques by inducing an anti-inflammatory response and reducing platelet aggregation 3,4,5. In contrast, AA facilitates plaque instability through the activation of inflammatory processes and platelet activation 6,7. Thus, having a low EPA/AA ratio may destabilize and progress the coronary plaques and cause subsequent adverse coronary event 8,9.

Source: Journal of Clinical Lipidology - December 2, 2022 Category: Lipidology Authors: Kiyoshi Asakura, Yoshiyasu Minami, Takako Nagata, Masahiro Katamine, Aritomo Katsura, Takuya Hashimoto, Daisuke Kinoshita, Junya Ako Tags: Original Research Source Type: research