Anti-Hu Antibodies in Patients With Neurologic Side Effects of Immune Checkpoint Inhibitors

Discussion
The presence of Hu-Ab identifies a subgroup of n-irAEs that consistently reproduce the phenotypes of Hu-Ab-related PNS, supporting the hypothesis of ICI triggering or unmasking PNS. As these patients show high disability and mortality, further studies are required to investigate the underlying immunopathogenic mechanisms and to improve the outcome of Hu-Ab n-irAEs.

Source: Neurology Neuroimmunology and Neuroinflammation - November 29, 2022 Category: Neurology Authors: Farina, A., Villagran-Garcia, M., Ciano-Petersen, N. L., Vogrig, A., Muniz-Castrillo, S., Taillandier, L., Michaud, M., Lefilliatre, M., Wang, A., Lepine, Z., Picard, G., Wucher, V., Dhairi, M., Fabien, N., Goncalves, D., Rogemond, V., Joubert, B., Honnor Tags: Research Article Source Type: research