Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF- κB pathway and neuroinflammation

CONCLUSIONS: This study demonstrates that ALPK1 is implicated in sterile inflammatory injury after acute brain ischemia, which provides first evidence for the therapeutic potential of ALPK1 inhibition in ischemic stroke.PMID:36274483 | DOI:10.1016/j.intimp.2022.109330

Source: International Immunopharmacology - October 24, 2022 Category: Allergy & Immunology Authors: Jing-Ying Li Zi-Xing Zheng Lin Liu Ou Du Neng-Wei Yu Yunyun Zou Seung-Yong Seong Jun-Rong Du Source Type: research