Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A Systematic Review and Meta-analysis

ConclusionsAn immediate depletion of Pax7+ cells in exercising skeletal muscle concurrent with a transient release of CD34+ cells suggest a replenishment of the local stem cell reserve from bone marrow. A protracted Pax7+ cell expansion in the muscle can be observed during 24 –72 h after resistance exercise. This result provides a scientific basis for exercise recommendations on weekly cycles allowing for adequate recovery time. Exercise-induced Pax7+ cell expansion in muscle remains significant at higher age, despite a lower stem cell reserve after age 50  years. More studies are required to confirm whether Pax7+ cell increment can occur after aerobic exercise.Clinical Trial RegistrationRegistered at the International Prospective Register of Systematic Reviews (PROSPERO) [identification code CRD42021265457].
Source: Sports Medicine - Category: Sports Medicine Source Type: research