Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8+ Regulatory T Cells

Discussion
Altogether, these results suggest a defect in the number and function of CD8+CD45RClow Tregs during MS relapse and an association of CD8+CD45RClow Tregs dysfunction with MS severity. Thus, CD8+CD45RClow/neg T cells might bring new insights into the pathophysiology and new therapeutic approaches of MS.

Source: Neurology Neuroimmunology and Neuroinflammation - October 20, 2022 Category: Neurology Authors: Benallegue, N., Nicol, B., Lasselin, J., Bezie, S., Flippe, L., Regue, H., Vimond, N., Remy, S., Garcia, A., Le Frere, F., Anegon, I., Laplaud, D., Guillonneau, C. Tags: Research Article Source Type: research