Clinical profile of patients with leber hereditary optic neuropathy (LHON): An ambispective study of North Indian Cohorts

Discussion: Clinical profile of 83 patients with both positive and negative mutations was analyzed. Twenty-three out of 161 patients (14.3%) tested positive for either of the three mutations. The majority of the patients harbored G11778A mutation (56.52%) followed by T14484C (34.78%) and G3460A (8.69%). No statistical difference could be noted between the clinical profiles of mutation-negative and -positive patients.

Source: Annals of Indian Academy of Neurology - October 19, 2022 Category: Neurology Authors: Vinny Wilson Prabhjit Kaur Sofia Singh Radhika P Ramachandran Vislavath Jyothi Karthik V Mahesh Aastha Takkar Giriraj Chandak Ramandeep Singh Source Type: research