Stanniocalcin 2 is upregulated by calcium-sensing receptor and protects human vascular smooth muscle cells from high phosphate-induced apoptosis

Conclusion This is the first evidence that STC2 is regulated by CaSR in HAoSMCs. CaSR activation and the subsequent STC2 increase have putative anti-apoptotic effects against high phosphate. Thus, calcimimetics are promising agents to treat vascular injury associated with uremia.
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research