Concentration ‐dependent effects of pro‐inflammatory cytokines on barrier function and tight junction protein expression in brain microvascular endothelial cells and the hypothermic and hyperthermic effects on tight junction protein expression

ConclusionsThe hypothermic suppression of TNF- α and IL-17 release may contribute to the maintenance of BBB function by ameliorating the decrease of TJP(s). In contrast, hyperthermia may decrease barrier function through a decrease in JAM-B expression. However, the contribution of changes in the JAM-B expression to the barrier function of BMVEC s remains to be clarified.

Source: Clinical and Experimental Neuroimmunology - September 17, 2022 Category: Neurology Authors: Tomohiro Matsui, Yuji Mochiduki, Yusuke Yoshida, Takenori Nitta Tags: ORIGINAL ARTICLE Source Type: research