Solifenacin Treatment After Intradetrusor Injections With Botulinum Toxin in Patients With Neurogenic Detrusor Overactivity

Conclusions: Our study shows that adding solifenacin improves patient satisfaction, increases the interval between reinjections, thus lowering costs, and improves maximum bladder capacity. Pdet was kept in safe ranges, but no statistically significant conclusions could be drawn regarding Pdet and PVR decrease related to adding solifenacin. Although our study is limited by the small series of patients and lack of randomization and placebo control group, the BoNT–solifenacin combination could be considered in NDO in terms of cost-effectiveness. Further studies would be beneficial.
Source: American Journal of Therapeutics - Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research