Tenofovir plasma concentrations related to estimated glomerular filtration rate changes in first-line regimens in African HIV-infected patients: ANRS 12115 DAYANA substudy

Conclusions In this population of mostly female HIV-1-infected African patients, tenofovir plasma overexposure was associated with PI/ritonavir and a time-dependent decrease in eGFR, probably via an inhibition of MRP2/MRP4 efflux transporters. The close monitoring over time of the eGFR using MDRD or CKD-EPI calculations and by using other biomarkers of renal disorder should be proposed as an alternative to therapeutic drug monitoring in resource-limited countries.

http://jac.oxfordjournals.org/cgi/content/short/70/5/1517?rss=1

Source: Journal of Antimicrobial Chemotherapy - April 13, 2015 Category: Microbiology Authors: Le, M. P., Landman, R., Koulla-Shiro, S., Charpentier, C., Sow, P.-S., Diallo, M.-B., Ngom Gueye, N. F., Ngolle, M., Le Moing, V., Eymard-Duvernay, S., Benalycherif, A., Delaporte, E., Girard, P.-M., Peytavin, G., on behalf of the DAYANA Study Group, on b Tags: Original research Source Type: research