PGE2 protects against heart failure through inhibiting TGF- β1 synthesis in cardiomyocytes and crosstalk between TGF-β1 and GRK2

Inflammation plays a central role in the development of heart failure. Prostaglandin E2 (PGE2) is a key mediator of the inflammatory process in the cardiovascular system. However, the role of PGE2 in heart failure is complex and controversial. A recent report suggested that PGE2 inhibits acute β adrenergic receptor (β-AR) stimulation-enhanced cardiac contractility. The aim of this study was to characterize the influence of PGE2 on chronic β-AR stimulation-induced heart failure. Male C57BL/6 J mice received isoproterenol (ISO) or vehicle for 4 weeks.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research