Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV
Objective(s):
To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV.
Design:
Cross-sectional study.
Methods:
We enrolled adults living with HIV who were IPT-naive or had completed IPT more than 6 months prior at HIV care clinics in western Kenya. We calculated TB signatures using gene expression data from qRT-PCR. We used multivariable linear regression to analyze the association between prior receipt of IPT or NTM sputum culture positivity with a transcriptional TB risk score, RISK6 (range 0–1). In secondary analyses, we explored the association between IPT or NTM positivity and four other TB transcriptional signatures.
Results:
Among 381 participants, 99.7% were receiving antiretroviral therapy and 86.6% had received IPT (completed median of 1.1 years prior). RISK6 scores were lower (mean difference 0.10; 95% confidence interval (CI): 0.06–0.15; P
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
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