[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer ’s disease pathology in APP/PS1 mice

Conclusions[18F]ROStrace identifies increased oxidative stress and neuroinflammation in APP/PS1 female mice, concurrent with increased amyloid burden midlife. Differences in oxidative stress during this crucial time may partially explain the sexual dimorphism in AD. [18F]ROStrace may provide a long-awaited tool to stratify at-risk patients who may benefit from antioxidant therapy prior to irreparable neurodegeneration.
Source: EJNMMI Research - Category: Radiology Source Type: research