The Longitudinal Relationship between Inflammatory Burden and Gait Speed is Influenced by White Matter Microstructural Characteristics: Secondary Analysis of the Health ABC Study. (I10-2A)

CONCLUSIONS: Sustained exposure to high IL-6 rather than the rate of change in IL-6 may adversely affect walking speed, potentially by influencing WM microstructural characteristics in older adults. Funding: N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, R01-AG028050, R01AG 027017, K07AG033174, R01-NR012459, Pittsburgh Pepper Center (P30 AG024827).Disclosure: Dr. Nadkarni has nothing to disclose. Dr. Boudreau has nothing to disclose. Dr. Lopez has received personal compensation for activities with Merz Pharma as a consultant. Dr. Aizenstein has nothing to disclose. Dr. Kritchevsky has nothing to disclose. Dr. Yaffe has received personal compensation for activities with Pfizer Inc., Medivation, and Novartis. Dr. Studenski has nothing to disclose. Dr. Newman has nothing to disclose. Dr. Rosano has nothing to disclose.

Source: Neurology - April 8, 2015 Category: Neurology Authors: Nadkarni, N., Boudreau, R., Lopez, O., Aizenstein, H., Kritchevsky, S., Yaffe, K., Studenski, S., Newman, A., Rosano, C. Tags: The Dynamic Brain in Health and Disease: Plasticity and Reprogramming Poster Presentations Source Type: research