Therapeutic Drug Monitoring of Vancomycin in Jordanian Patients. Development of Physiologically-Based Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary Excretion Classi fication System (SECS)
Drug Res (Stuttg) DOI: 10.1055/a-1852-5391Vancomycin is a commonly used antibiotic for multi-drug resistant gram-positive
infections treatment, especially methicillin-resistant Staphylococcus aureus
(MRSA). Despite that, it has wide individual pharmacokinetic variability and
nephrotoxic effect. Vancomycin trough concentrations for 57 Jordanian patients
were measured in plasma and saliva through immunoassay and liquid
chromatography-mass spectrometry (LC-MS/MS), respectively. Plasma levels
were within accepted normal range, with exception of 6 patients who showed
trough levels of more than 20 μg/ml and vancomycin was
discontinued. Bayesian dose-optimizing software was used for patient-specific
pharmacokinetics prediction and AUC/MIC calculation. Physiological-based
pharmacokinetic (PBPK) vancomycin model was built and validated through
GastroPlus™ 9.8 using in-house plasma data. A weak correlation
coefficient of 0.2478 (P=0.1049) was found between plasma and saliva
concentrations. The suggested normal saliva trough range of vancomycin is
0.01906 to 0.028589 (μg/ml). Analysis of variance showed
significant statistical effects of creatinine clearance and albumin
concentration on dose-normalized Cmin plasma and saliva levels respectively,
which is in agreement with PBPKmodeling. It can be concluded that sal...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Arabyat, Majd Abdul-Sattar, Ahmad Al-Fararjah, Feras Al-Ghazawi, Ahmad Rabayah, Ayman Al-Hasassnah, Rakan Mohmmad, Walid Al-Adham, Ibrahim Hamadi, Salim Idkaidek, Nasir Tags: Original Article Source Type: research
More News: Drugs & Pharmacology | Gastroenterology | Infectious Diseases | Jordan Health | Middle East Health | MRSA | Staphylococcus Aureus | Statistics | Superbugs