CO100 Correlations between Patient- and Caregiver-Reported Pruritus from PEDFIC 1: Evaluation of Prucision Data in Patients with Progressive Familial Intrahepatic Cholestasis

10.1016/j.jaip.2022.01.038Pruritus can be a debilitating symptom for patients with progressive familial intrahepatic cholestasis (PFIC), a disease that commonly presents in young children. In the phase 3 PEDFIC 1 study (NCT03566238), odevixibat, an ileal bile acid transporter inhibitor, reduced pruritus compared with placebo based on caregiver report in children with PFIC using the PRUCISION scale. Patient-reported pruritus data were also collected from patients aged ≥8 years. This analysis examines the correlation between patient- and caregiver-reported pruritus scores in PEDFIC 1.

Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: C Clemson, Q Ni, P Horn Source Type: research