WDFY3 mutation alters laminar position and morphology of cortical neurons

ConclusionsOur genetic approach revealed several cell autonomous requirements of WDFY3 in neuronal development that could underlie the pathogenic mechanisms ofWDFY3-related neurodevelopmental conditions. The results are also consistent with findings in other ASD animal models and patients and suggest an important role for WDFY3 in regulating neuronal function and interconnectivity in postnatal life.

http://link.springer.com/10.1186/s13229-022-00508-3

Source: Molecular Autism - June 22, 2022 Category: Molecular Biology Source Type: research