The History of Diagnosis and Treatment of MS: a Brief Overview

AbstractPurpose of ReviewThis overview of the history of diagnosis and treatment of multiple sclerosis serves as an introduction to the rich history of multiple sclerosis, and shows we are on a continuum of incremental advances that date back centuries.Recent FindingsThe current understanding of MS demonstrates a dramatic series of advances and this brief historical overview will provide some context for these discoveries.SummaryAlthough cases we would now recognize as multiple sclerosis can be found in older literature and diaries, the contribution of Jean-Martin Charcot at the Salp êtrière in Paris in 1868 was to frame the clinical and pathological features of a disorder he calledla scl érose en plaque disséminées. Soon after, reports came from many countries. Over the next half-century, the diagnosis was a clinical conclusion with no confirmatory tests. Some CSF and evoked potential tests later helped but it remained for the MRI imaging and oligoclonal banding to substantially aid the clinical diagnosis. It is tempting to think that therapy is new in MS, but in previous centuries, hundreds of drugs, procedures, and surgeries were applied to patients with MS, many more than we use today. It remained for the development of the randomized clinical trial to show which therapies were beneficial and safe. Everything changed in 1993 when the first of a long list of new therapies was approved, therapies that were shown to alter the activity and outcome of the disease.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research