Bone healing differences in sexes under ibuprofen treatment

AbstractBone healing is comprised of a complex cascade of events to repair the fractured bone and gain functionality. This process is affected by numerous local and systemic factors such as the degree and extent of the injury, cardiovascular disorders, age, sex, chronic diseases, nutritional status, stimulants, and drugs used. The current study aimed to resolve the relationship of ibuprofen treatment and sex-specific bone healing in a rat model of the tibial fraction. The bone defect was inflicted by a tibial monocortical osteotomy with a 1-mm diameter. Male and female rats were injected with saline or ibuprofen (30  mg/kg/day) for 2 weeks post-surgery. Bone healing quality was assessed after 4 weeks of the experiment. Moreover, the serum IL1B level was measured and associated with bone healing quality measures. Only the female rats with ibuprofen treatment showed an integration of adjacent and cortical bone s, which indicates an accelerated bone healing in these animals. In contrast, the males with no ibuprofen treatment had the highest serum IL1B concertation. In general, the serum IL1B was negatively correlated with bone cellularity. Our result suggests a beneficial effect of the short ibuprofen trea tment on bone healing but mainly for females. This preliminary study encourages additional clinical and experimental research to adapt a sex-specific post-surgical analgesic treatment to improve the bone healing quality of the patients.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research