Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
CONCLUSIONS: Collectively, this study showed that calycosin might attenuate OVA-induced airway inflammation and remodeling in asthmatic mice via preventing ILC2 activation and macrophage M2 polarization. Our study might contribute to further study of asthmatic therapy.PMID:38650035 | PMC:PMC11036756 | DOI:10.1186/s40360-024-00751-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 22, 2024 Category: Drugs & Pharmacology Authors: Chunyan Tian Qi Liu Xiaoyu Zhang Zhuying Li Source Type: research
Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
CONCLUSIONS: Collectively, this study showed that calycosin might attenuate OVA-induced airway inflammation and remodeling in asthmatic mice via preventing ILC2 activation and macrophage M2 polarization. Our study might contribute to further study of asthmatic therapy.PMID:38650035 | DOI:10.1186/s40360-024-00751-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 22, 2024 Category: Drugs & Pharmacology Authors: Chunyan Tian Qi Liu Xiaoyu Zhang Zhuying Li Source Type: research
Treatment for Covid-19 with SARS-CoV-2 neutralizing antibody BRII-196(Ambavirumab) plus BRII-198(Lomisivir): a retrospective cohort study
CONCLUSION: The neutralizing antibody therapy, BRII-196 plus BRII-198 could shorten LOS and interval of Covid-19 nucleic acid from positive to negative. However, it didn't show efficacy for improving clinical outcomes among severe or critical cases.PMID:38641625 | PMC:PMC11027409 | DOI:10.1186/s40360-024-00753-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 19, 2024 Category: Drugs & Pharmacology Authors: Qin Yalan Hao Lingfang Liu Xisong Liang Run Zhang Junjing Zhang' An Source Type: research
Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital
CONCLUSIONS: As a result, PAIR criteria can identify clinically relevant DRPs in patients with CKD and is a new, validated tool to be used in Turkey, but may not be adequate for patients receiving dialysis. Therefore, it needs to be reviewed and updated for dialysis patients.PMID:38637817 | PMC:PMC11025200 | DOI:10.1186/s40360-024-00754-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 18, 2024 Category: Drugs & Pharmacology Authors: Aysel Pehlivanli Sayeste Akkan Eren Sule Sengul Bilgen Basgut Sehsuvar Erturk A Tanju Ozcelikay Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | PMC:PMC10976767 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
