Rosuvastatin or Atorvastatin , Which is good and safe ?
Statins belong to a group of drugs, stolen and reengineered from the blueprint of natural Chinese red yeast rice (Monocoline K) in the late 1980s. The rest is the remarkable history in the pharma industry.
Statins directly interrupt the cholesterol synthesis by blocking HMG-CoA within the hepatocytes. It significantly lowers the LDL, fights human vascular atherosclerosis. It makes the plaque either regress, prevent progress, make it harder and in the process make them less vulnerable . There are innumerable studies that document the evidence. Statin has become a must-prescribe drug in any one with clinically establishe...
Source: Dr.S.Venkatesan MD - November 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha atorvastatin vs rosuvastatin avert study bmj esc jamanetwork lancet lipid association lodestar study lodestar trial bmj nejm saturn trial simvastatin statins which statin superior Source Type: blogs
Optimal lipid control & Oligonucleotides
Sharing a presentation on lipid control done in 2020. This talks about newer strategies beyond statins.
PDF version
lipid-metabolism Download
(Source: Dr.S.Venkatesan MD)
Source: Dr.S.Venkatesan MD - August 8, 2021 Category: Cardiology Authors: dr s venkatesan Tags: lipids lipid metabolism Uncategorized dyslipdemia inclisiran j curve in ldl j curve in lipid control pcsk blockers ppt on lipid metabolism siRNA pcsk lipid metabolism ssss trial simvastatin statins in primary prevention Source Type: blogs
Ignoring Drug Trademarks
Erika Lietzan (University of Missouri), Ignoring Drug Trademarks, Wake Forest L. Rev. (forthcoming): If you walk into a pharmacy with a prescription for Merck ’s ZOCOR, which contains simvastatin, the pharmacist will probably give you a product containing simvastatin made by... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - July 1, 2021 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Lowering cholesterol protects your heart and brain, regardless of your age
High or abnormal cholesterol levels, inflammation, and endothelial dysfunction play a key role in atherosclerosis and plaque buildup, the most common cause of heart attacks and strokes. (Endothelial dysfunction refers to impaired functioning of the inner lining of blood vessels on the heart’s surface. It results in these vessels inappropriately narrowing instead of widening, which limits blood flow.) There are many different types of cholesterol, including high density lipoprotein (HDL, or good, cholesterol); triglycerides (a byproduct of excess calories consumed, which are stored as fat); and low-density lipoprotein (LD...
Source: Harvard Health Blog - February 24, 2021 Category: Consumer Health News Authors: Hanna Gaggin, MD, MPH Tags: Drugs and Supplements Healthy Eating Heart Health Source Type: blogs
Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Sedentary Behavior Raises the Risk of Cancer Mortality
https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/
Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a r...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nanoparticles Containing Cyclodextrins to Sequester Cholesterol Do Well in an Atherosclerosis Animal Model
Cyclodextrins bind to cholesterol. This aspect of their biochemistry has been used by the Underdog Pharmaceuticals team to produce a cyclodextrin that binds the form of toxic oxidized cholesterol known as 7-ketocholesterol. 7-ketocholesterol builds up with age and is implicated in a range of age-related conditions, particularly atherosclerosis, as altered cholesterols cause dysfunction in the macrophage cells responsible for removing cholesterols and other lipids from blood vessel walls. The outcome is the creation of fatty lesions that narrow and weaken blood vessels in older individuals, an ultimately fatal condition. Re...
Source: Fight Aging! - June 24, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Beyond heart health: Could your statin help prevent liver cancer?
Liver cancer is hard to treat. It’s a top-five cause of cancer-related death worldwide and a growing cause of cancer-related deaths in the United States. Since liver cancer is often found at a late stage, when treatment has limited benefit, there has been increasing interest in prevention. That’s where statin medications might come in.
Liver cancer is usually caused by chronic liver disease, so an important way to prevent liver cancer is to treat the underlying trigger. For example, curing hepatitis C infection — an important cause of chronic liver disease — reduces the risk of liver cancer. However, if the liver d...
Source: Harvard Health Blog - January 27, 2020 Category: Consumer Health News Authors: Irun Bhan, MD Tags: Cancer Drugs and Supplements Health Source Type: blogs
MKSAP: 38-year-old woman with primary membranous glomerulopathy
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 38-year-old woman is evaluated during a follow-up visit for primary membranous glomerulopathy. Diagnosis was made by kidney biopsy 4 months ago, and she was found to be positive for anti–phospholipase A2 receptor (PLA2R) antibodies. Medications are furosemide, losartan, and simvastatin. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 16, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Nephrology renal cell renal cell carcinoma Source Type: blogs
Fight Aging! Newsletter, January 21st 2019
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins.
Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - January 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nattokinase and Reversal of Atherosclerotic Lesions
Atherosclerosis is one of the great killers. Fatty deposits form in blood vessels walls, narrowing and weakening the vessels. Eventually something ruptures, and the result is a stroke or heart attack, but even absent that the condition can narrow vessels sufficiently to cause fatal coronary artery disease. Even with modern medicine, the condition is inexorable: the toolkit doesn't yet include a way to more than slightly reverse the buildup of these plaques, and medical professionals must focus on ways to incrementally slow the progression of atherosclerosis rather than delivering any true cure.
One of the side-effec...
Source: Fight Aging! - January 15, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Does Christmas Have To Do With Genomics?
Do you have the feeling that genomics is all around this year and you cannot escape DNAs, SNPs, chromosomes and double spirals wherever you look? Do you suspect that even Billy Mack is considering a change to “Genes are all around you” in everyone’s favorite holiday movie, Love Actually? Well, that won’t be a surprise as Christmas and genetics have more in common than you think – and scientists are even working on figuring out Santa’s genetic make-up.
Gene-edited Christmas trees and Santa’s DNA
If it’s all in our genes, the explanation for the Grinch hating the holidays or Santa’s incredible working capac...
Source: The Medical Futurist - December 18, 2018 Category: Information Technology Authors: nora Tags: Genomics Patients christmas Christmas tree december dinner DNA dna testing food future Gene genes genetics holiday holidays Innovation nutrigenomics pharmacogenomics Santa technology Source Type: blogs
Nutritional Lipidology
The statin drug industry and their willing and eager servants, i.e., doctors, have managed to prop up a drug franchise that has reaped hundreds of billion of dollars over the years while providing little benefit but plenty of harm. Although I’ve discussed these issues many times here in the Wheat Belly Blog, the Wheat Belly books, and more recently in the Undoctored book and Blog, it bears exploring further. I keep on hoping that clarity, logic, evidence, truth and repetition overcome our lack of billions of dollars in marketing that Big Pharma controls, a genuine David-vs-Goliath situation.
I call all the varied c...
Source: Wheat Belly Blog - December 17, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates cardiovascular cholesterol heart lipoproteins statin undoctored wheat belly Source Type: blogs
Pharmacogenomics: The Science of Personalizing Drugs Based On DNA
Individuals share about 99.97 percent of their DNA and only the remaining 0.03 percent is responsible for the differences in skin, hair or eye color, height, shoe size or sunspots. Scientists discovered somewhat recently that our bodies also metabolize drugs differently so it would make sense to prescribe medications based on the knowledge hidden in our DNA. In some cases, physicians already do that. Here’s what you need to know about pharmacogenomics and the future of prescription drugs.
It’s all in your genes
Why do some people eat creamy French cakes all the time, only do sports when they have to run after the bus a...
Source: The Medical Futurist - November 27, 2018 Category: Information Technology Authors: nora Tags: Future of Pharma Genomics Medical Professionals Patients Researchers DNA dna testing drugs genetics Health Healthcare Innovation medication pharmacogenetics pharmacogenomics precision health precision medicine technology Source Type: blogs
MKSAP: 67-year-old woman with degenerative joint disease
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 67-year-old woman is evaluated during a routine examination. She has a history of hip and knee pain related to degenerative joint disease. The joint pain is now well controlled with diclofenac, which was started 3 months ago. A previous trial of high-dose acetaminophen was not effective. She does not have any gastrointestinal symptoms, and she takes the diclofenac with food most of the time. Her medical history is otherwise notable for type 2 diabetes mellitus, hyperlipidemia, and hypertension. Her parents bot...
Source: Kevin, M.D. - Medical Weblog - March 3, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Gastroenterology Source Type: blogs
What Kmart ’s Settlement Says About Health Care Fraud
This reportedly violated regulations requiring pharmacies to apply their usual and customary charges when billing government payers.
The DOJ claims that “[t]he government’s resolution of this matter illustrates the government’s emphasis on combating health care fraud,” It might more accurately have said that the settlement adds to the mountain of evidence showing that the government cannot control even the most obvious forms of health care fraud, a point we make at length in our forthcoming book, Overcharged: Why Americans Pay Too Much For Health Care.
For one thing, at the very same time government payers were hon...
Source: The Health Care Blog - February 1, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Charles Silver David Hyman K-Mart Lisinopril Source Type: blogs
