COVID-19: Hidden Coinfections and Chain Reactions Parasitic Infectious Relationships within Us
By SIMON YU, MD, LT COL, USA (Ret)
Dr. Tom Frieden, former director of the Centers for Disease Control and Prevention (CDC), opened up a new front in the Coronavirus War by saying we don’t just need to treat the acute disease, we need to treat the underlying conditions that make people more susceptible to serious disease progression. He focused on heart disease, and managing mitigating risk factors such as CVD, diabetes, hypertension and smoking in order to increase people’s odds for recovery. The initial focus has been pneumonia and acute respiratory distress syndrome (ARDS), with risk factors including asthma, chr...
Source: The Health Care Blog - April 15, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 CDC chronic disease holistic care Pandemic SDoH Source Type: blogs
Drugs for COVID-19: A Publishing Epidemic
As of April 9, PubMed listed 2,868 scientific publications which incorporate the word “COVID”. 323 of these (11.3%) were related to drugs under study for treatment of the disease. No fewer than thirty-one such drugs had been proposed since this pandemic first appeared on the planet four months earlier.
Graph 1 depicts the cumulative numbers of COVID-19 infection (per 100,000 global population) and introductions of relevant drugs into the Literature during February 14 to April 3. Note that both increased by a factor of approximately 16-fold during this period.
In a...
Source: GIDEON blog - April 12, 2020 Category: Databases & Libraries Authors: Uri Blackman Tags: Epidemiology Graphs Source Type: blogs
The Debacle of Hydroxychloroquine and Azithromycin for COVID19
I discussed the use of hydroxychloroquine and azithromycin for patients with COVID19 on my March 27th edition of This Week in Cardiology Podcast.
This is an important topic not only because of the specifics of treating patients but also vital because it shows how easily human beings can be misled.
Here is a an edited transcript of my words:
A conversation I had with my Dad this week made me realize the seriousness of this matter. My Dad is a retired insurance executive with a background in electrical engineering.
He is smart, but I could not convince him that the evidence prompting people to advoc...
Source: Dr John M - April 5, 2020 Category: Cardiology Authors: Dr John Source Type: blogs
This treatment could save your life – COVID-19 and Convalescent Plasma Therapy
Ajay Kohli
Vinay Kohli
Chitra Chhabra Kohli
By CHITRA CHHABRA KOHLI MD, AJAY KOHLI MD, and VINAY KOHLI MD, MBA
With a doubling time of cases estimated between 3 days within the U.S. and about 6 days globally (at the time of this writing) COVID-19 is demonstrating its terrifying virulence as it spreads across the world.
What’s perhaps equally terrifying, if not more, is the absence of a known cure or treatment plan for COVID-19. While there has been a lot of attention focused on Hydroxychloroquine and Azithromycin, there has been debate on the scientific validity of these treatment options, either as thera...
Source: The Health Care Blog - March 30, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Patients Physicians Ajay Kohli Azithromycin convalescent plasma therapy coronavirus COVID-19 treatment hydroxychloroquine Pandemic Vinay Kohli Source Type: blogs
Azithromycin and COVID-19
ConclusionA small, preliminary COVID-19 clinical study reported complete clearance of virus after combined administration of azithromycin and hydroxychloroquine as measured by realtime PCR of nasopharyngeal swabs. No study of azithromycin alone was conducted. Despite azithromycin's reputation as an antibacterial agent, scattered reports of in vivo and in vitro antiviral activity for this drug have been reported. (Source: Depth-First)
Source: Depth-First - March 24, 2020 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Coronavirus, Chloroquine, and “Off‐label” Use
Jeffrey A. SingerAt a Coronavirus Task Force briefing last week, President Trumpincorrectly told the press that the antimalarial drug chloroquine had already gone through the Food and Drug Administration ’s approval process for the treatment of COVID-19 infection:“They’ve gone through the approval process, it’s been approved and they did it, they took it down from many, many months to immediate.” He was later corrected by the FDA Commissioner, who said the approval process had not and will not be completed until controlled clinical trials have convin ced the agency.Many people might therefore conclude that d...
Source: Cato-at-liberty - March 23, 2020 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Teenager with chest pain and slightly elevated troponin. What happens then?
This is a previously healthy male teenager who was awoken by chest pain. He was seen at another hospital and found to have a slightly elevated troponin, then underwent a CT pulmonary angiogram (PE) protocol which revealed a right sided pneumonia. He was treated with Ceftriaxone and azithromycin.p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Calibri; background-color: #fefefe}The pain is described as located in the midsternal area, radiating to the right arm, described as 8-9/10 and worse with deep inspirations. He endorsed cough, fever, and body aches in the previous day...
Source: Dr. Smith's ECG Blog - December 9, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Funtabulously Frivolous Friday Five 281
Dr Neil Long Funtabulously Frivolous Friday Five 281
It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 281 (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - May 31, 2019 Category: Emergency Medicine Authors: Dr Neil Long Tags: FFFF Alice Springs Antibiotics azithromycin blepharoclonus claw hand clindamcin doxycycline Leonardo da Vinic metronidazole moxifloxacin Paget Schrotter syndrome rifampin TMP/SMX ulnar palsy Urschel's Sign Source Type: blogs
Pediatric Conjunctivitis a Simple Diagnosis Until It Isn’t
Conjunctivitis is a common condition and easy enough to treat, but several uncommon conjunctivitis syndromes require more care and should not be missed.Conjunctivitis is either infectious (viral or bacterial) or noninfectious (allergic or nonallergic). Viral infections are more common in adults, bacterial ones in children, usually caused by Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Adults tend to have more S. aureus infections, while the other pathogens are more common in children. An adenovirus is typically responsible for viral-associated infections in conjunct...
Source: M2E Too! Mellick's Multimedia EduBlog - March 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
The Perfect Office Note? SOAP, APSO or aSOAP?
By HANS DUVEFELT MD
I’ve been toying with this dilemma for a while: SOAP notes (Subjective, Objective, Assessment, Plan) are too long; APSO just jumbles the order, but the core items are still too far apart, with too much fluff in between. We need something better – aSOAP!
Electronic medical record notes are simply way too cumbersome, no matter in what order the segments are displayed, to be of much use if we quickly want to check what happened in the last few office visits before entering the exam room.
It is time we do something different, and I believe the solution is under our noses every day, at least if we rea...
Source: The Health Care Blog - January 16, 2019 Category: Consumer Health News Authors: matthew holt Tags: Physicians EMR Hans Duvefelt Patient Notes Source Type: blogs
Fight Aging! Newsletter, January 7th 2019
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup.
This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - January 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at the Rejuvenation Research and Advocacy of 2018
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging
Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System
An Interview with a Programmed Aging Theorist
An Interview with Reason at the Life Extension Advocacy Foundation
An Interview on Mitochondrial Damage and Dysfunction in Aging
An Interview with Vadim Gladyshev on Research into the Causes of Aging
An Interview with Jim Mellon, and Update on Juvenescence
A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation
An Interview with Peter de Keize...
Source: Fight Aging! - December 31, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, November 19th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - November 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Initial Evidence for the Antibiotics Azithromycin and Roxithromycin to be Senolytic
Researchers here report on two new senolytic compounds identified in the existing library of approved drugs, based on screening work in cell cultures. It is worth bearing in mind that drug candidates that demonstrate good results in cell culture quite often fail to show promise when tested in animals, so it is wise to be patient as new senolytics work their way through the research and development pipeline. There will be a lot more of this sort of thing in the years ahead, as ever greater amounts of funding pour into finding new ways to selectively destroy senescent cells. Any senolytic approach that removes a significant ...
Source: Fight Aging! - November 16, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Thoughts on a 23-year-old athlete dying from the Lemierre Syndrome
K-State football team to honor rower Samantha Scott, who died of Lemierre’s Syndrome
Every time I read such a story my heart breaks, a small piece each time. More physicians have become aware of the Lemierre syndrome. We must also educate patients and families that sore throats in adolescents and young adults can become life threatening.
Why did she die? The article does not have enough detail to develop a firm conclusion. I can speculate on several reasons from multiple discussions with both survivors and families of adolescents who died. We also have some unpublished survey data that informs my speculations.
Wh...
Source: DB's Medical Rants - November 3, 2018 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
