Gandouling alleviates nerve injury through PI3K/Akt/FoxO1 and Sirt1/FoxO1 signaling pathway to inhibit autophagy in the rats model of Wilson's disease
ConclusionFurthermore, it inhibited the expression of autophagy genes Atg12 and Gabarapl1. In summary, our work provides new insights into the potential mechanisms of GDL repairing WD neuronal damage through autophagy pathways. (Source: Brain and Behavior)
Source: Brain and Behavior - November 27, 2023 Category: Neurology Authors: Li Chen,
Wangyang Xu,
Yuting Zhang,
Hao Chen,
Yanquan Han Tags: ORIGINAL ARTICLE Source Type: research
Changes in brain susceptibility in Wilson ’s disease patients: a quantitative susceptibility mapping study
To assess changes in the susceptibility of the caudate nucleus (CN), putamen, and globus pallidus (GP) in patients with neurological and hepatic Wilson's disease (WD) by quantitative susceptibility mapping (QSM). (Source: Clinical Radiology)
Source: Clinical Radiology - November 21, 2023 Category: Radiology Authors: W. Deng, J. Zhang, J. Yang, Z. Wang, Z. Pan, X. Yue, R. Zhao, Y. Qian, Y. Yu, X. Li Source Type: research
Challenges and dilemmas in pediatric hepatic Wilson's disease
World J Hepatol. 2023 Oct 27;15(10):1109-1126. doi: 10.4254/wjh.v15.i10.1109.ABSTRACTWilson disease is an autosomal recessive disorder affecting the ATP7B gene located on chromosome 13q. This leads to copper deposition in various organs, most importantly in the liver and brain. The genetic mutations are vast, well reported in the West but poorly documented in developing countries. Hence the diagnosis is made with a constellation of clinico-laboratory parameters which have significant overlap with other liver diseases and often pose a significant dilemma for clinicians. Diagnostic scoring systems are not fool-proof. The ava...
Source: World Journal of Hepatology - November 16, 2023 Category: Gastroenterology Authors: Upasana Ghosh Moinak Sen Sarma Arghya Samanta Source Type: research
