In-vitro antiviral screening of some thiopyranothiazoles
Chem Biol Interact. 2023 Oct 8:110738. doi: 10.1016/j.cbi.2023.110738. Online ahead of print.ABSTRACTThiopyranothiazoles represent a promising class of drug-like molecules with broad pharmacological profiles. Some novel derivatives of isothiochromeno [4a,4-d]thiazole and chromeno [4',3':4,5]thiopyrano [2,3-d]thiazole were synthesized and screened against diverse viruses: coronavirus SARS, Influenza Viruses of type A and type B, Adeno- and Rhinovirus, Dengue Fever Virus, Respiratory Syncytial Virus, Rift Valley Fever Virus, Tacaribe Virus, Venezuelan Equine Encephalitis Virus, as well as Vaccinia and Human Cytomegalovirus. ...
Source: Chemico-Biological Interactions - October 10, 2023 Category: Molecular Biology Authors: Anna Kryshchyshyn-Dylevych Danylo Kaminskyy Roman Lesyk Source Type: research
In-vitro antiviral screening of some thiopyranothiazoles
Chem Biol Interact. 2023 Oct 8:110738. doi: 10.1016/j.cbi.2023.110738. Online ahead of print.ABSTRACTThiopyranothiazoles represent a promising class of drug-like molecules with broad pharmacological profiles. Some novel derivatives of isothiochromeno [4a,4-d]thiazole and chromeno [4',3':4,5]thiopyrano [2,3-d]thiazole were synthesized and screened against diverse viruses: coronavirus SARS, Influenza Viruses of type A and type B, Adeno- and Rhinovirus, Dengue Fever Virus, Respiratory Syncytial Virus, Rift Valley Fever Virus, Tacaribe Virus, Venezuelan Equine Encephalitis Virus, as well as Vaccinia and Human Cytomegalovirus. ...
Source: Chemico-Biological Interactions - October 10, 2023 Category: Molecular Biology Authors: Anna Kryshchyshyn-Dylevych Danylo Kaminskyy Roman Lesyk Source Type: research
Is using the Gail model to calculate the risk of breast cancer in the Venezuelan population justified?
CONCLUSION: There is no conclusive evidence to consider that the GM is applicable to Venezuelan women due to its low precision since it only identified 41% of the patients who had BC as high risk; however, when the factors are analysed separately, we found a higher probability of a positive Gail with statistical significance in EM <11 years, PHBC, previous biopsy and age at first birth 25-29 years; When stratifying by age, we observed that the age at first birth 25-29 years in women aged 40 or less increases the probability of a positive Gail. It is necessary to develop new risk assessment models that are adapted to our...
Source: Ecancermedicalscience - October 6, 2023 Category: Cancer & Oncology Authors: Josepmilly Del Valle Pe ña Colmenares Carmen Cristina Garc ía Yazmin Jos é Velásquez Velásquez Leider Arelis Campos Pino Álvaro Gómez Rodríguez Wladimir Jos é Villegas Rodríguez David Jos é González Vargas Douglas Jos é Angulo Herrera Source Type: research
