How quickly does wheatlessness unfold?
Wheatlessness: the happy, healthy state achieved by not eating wheat. A frequently asked question: Once you eliminate wheat, how fast do the benefits occur? Well, it depends. It depends on what health issue we are discussing, what organ system, and how far along the process of wheat destruction you were. Nonetheless, there are a number of common patterns that develop once you decide to eliminate all things wheat in your life: Gastrointestinal Acid reflux, bowel urgency–5 days is typical for these conditions to reduce or go away entirely. Ulcerative colitis, Crohns–These complex inflammatory conditions require...
Source: Wheat Belly Blog - June 14, 2013 Category: Cardiology Authors: Dr. Davis Tags: Wheat-ectomy Wheat-elimination success stories Source Type: blogs

First multiple "Overselling the microbiome award": the Daily Mail article on Germs
At the recent "Future of Genomic Medicine" meeting, George Church gave me some grief over my "Overselling the microbiome award" because he thinks (rightly) that some people also undersell the microbiome. So I set out today to find an example to give out such an award.  And within seconds I bumped into this: Germs: There are bugs that cure infections, protect against stroke and even keep your skin clear | Mail Online in the Daily Mail.  Wow.  And not in a good way.  Oh well, so much for the underselling award.  Just the title made me cringe.  And so so so so many of the details are...
Source: The Tree of Life - March 25, 2013 Category: Medical Scientists Authors: Jonathan Eisen Source Type: blogs

Ulcerative colitis tamed
Traci posted this wonderful story of her dramatic relief from years of ulcerative colitis: Dr. Davis, For 24+ years I have suffered from Ulcerative Colitis (UC). This past Christmas, my stepmother recommend that I read your Wheat Belly book. I did because I had decided to remove carbs from my diet at the beginning of the year. She said your book would be a great supplement to my carb reduction. I had no idea that by reading your book my symptoms of UC would disappear!!! Normally, I am treated with a medicine called Remicade which is administered via IV. Usually I receive this medicine every 2 months. Guess what??? It’s ...
Source: Wheat Belly Blog - March 6, 2013 Category: Cardiology Authors: Dr. Davis Tags: Ulcerative colitis Source Type: blogs

The happy “coincidences” of wheatlessness
Wheat Belly Blog reader, Limor, posted this triumphant story of freedom from the health-destroying bonds of wheat: You validated what I have felt for so many years!! I read you book and watched your lectures over and over again and was fascinated by your knowledge and findings. I am a therapist in NYC specializing in Eating Disorders and I also recovered from Anorexia and Bulimia. I have been gluten-free for over a year and, after reading your book, I am working hard on being wheat-free. Prior to being wheat-free, I suffered severe pains and cramps in my stomach. After several failed attempts to ask various doctors why I...
Source: Wheat Belly Blog - February 26, 2013 Category: Cardiology Authors: Dr. Davis Tags: Eating disorderes Wheat-elimination success stories Source Type: blogs

Chef Pete Evans goes wheat-free!
Australian chef and TV personality, Pete Evans, asked me to write a section for his new cookbook: Over the last 12 months we have been working on a new cookbook, which will be available in about a years time [February 2014]. Dr William Davis, a preventative cardiologist who wrote “WHEAT BELLY” (a must read book) has kindly shared his research for our new book, along with a host of other highly respected health and wellness pioneers and experts. And for the record the only flour we use at home is coconut and almond flours. Pete tells me that, in the new cookbook, “there will be no recipes featuring wheat&...
Source: Wheat Belly Blog - February 24, 2013 Category: Cardiology Authors: Dr. Davis Tags: Uncategorized Source Type: blogs

Celiac is not a disease
. Lest you think I’ve gone off my rocker, let me explain. Say that, of 100 people you know who smoke, only 1 gets lung cancer. Do we declare that the only person who has problems with cigarettes is the poor unfortunate guy or girl with the one lung cancer? Shall we ignore the 60 cases of chronic bronchitis and emphysema, the 10 abdominal aortic aneurysms, the 5 thoracic aortic and iliofemoral aneurysms, the oral, tongue, and laryngeal cancers, and the several dozen other conditions that typically develop in smokers–but not as imminently fatal as lung cancer? In other words, do we dismiss all these conditions ...
Source: Wheat Belly Blog - February 5, 2013 Category: Cardiology Authors: Dr. Davis Tags: Celiac disease Source Type: blogs

Mipomersen Approved (Bonus Antisense Roundup Included)
So Isis and their partner Sanofi have received FDA approval for mipomersen (branded as Kynamro). Late last year, the European Medicines Agency turned them down, which has people wondering about the drug's future, but here they are, albeit with a warning on the label about liver toxicity. Mipomersen is designed to lower the Apo-B lipoprotein in people with the most severe (homozygous) form of familial hypercholesterolemia. That's a small patient population, but they're definitely in need of help. The really significant thing about this approval, in my mind, is that it's a pure antisense therapy, and it comes about twenty y...
Source: In the Pipeline - January 31, 2013 Category: Chemists Tags: Clinical Trials Source Type: blogs

MKSAP: 38-year-old man with ulcerative colitis
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.A 38-year-old man is evaluated during a routine examination. He was diagnosed with ulcerative colitis 10 years ago and is currently asymptomatic. His last colonoscopy, performed at the time of diagnosis, showed mildly active extensive colitis extending to the hepatic flexure. There is no family history of colon cancer or colon polyps. His only medication is mesalamine.On physical examination, vital signs are normal. Abdominal examination is normal. Laboratory studies, including a complete blood count, liver chemis...
Source: Kevin, M.D. - Medical Weblog - January 26, 2013 Category: Family Physicians Tags: Conditions GI Source Type: blogs

Overselling the microbiome: University Bern press release uses slight of hand to make mouse study seem to be about people
Interesting new paper came out recently on "Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity."  It is alas in Science so it is not available openly. Anyway there are some news stories about the article where you can get the gist of it.  Best one is probably the blog post by Christine Gorman: Transplanted Bacteria Turn Up Testosterone to Protect Mice against Diabetes.  The story is pretty interesting. For those who do not know I have been a bit obsessed about the connection between diabetes and the microbiome for a while.  See my Ted talk for example where ...
Source: The Tree of Life - January 19, 2013 Category: Medical Scientists Authors: Jonathan Eisen Source Type: blogs

USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics. Feature Disease 45, X chromosome Turner’s syndrome 5-HIAA increased in urine Carcinoid syndrome Aganglionic rectum Hirschsrpung’s disease Apple-core sign on barium enema Colon cancer Arched back (opisthotonos) Tetanus Argyll-Robertson pupil Syphilis Ash leaf on forehead Tuberous sclerosis Auer rods  Acute myelogenous leukemia Austin Flint murmur Aortic regurgitation...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs

Dysplasia in Inflammatory Bowel Disease
As we all know, chronic inflammatory bowel disease (IBD) presents a risk for dysplasia and subsequent malignancy in patients with long standing disease.The risk for adenocarcinoma increases with a number of factors includingthe linear extent of disease within the bowel,early age at onset of disease,severity of disease and duration of disease.The pathologic reporting of endoscopic biopsy specimens with inflammatory bowel disease must convey the information the clinician needs in a clear and consistent manner in order to properly manage the patient's disease.Every biopsy report should, of course, give an assessment of the di...
Source: Oncopathology - September 24, 2009 Category: Cancer & Oncology Tags: Dysplasia in Inflammatory Bowel Disease Source Type: blogs